Quantitative spectroscopic imaging for non-invasive early cancer detection.
نویسندگان
چکیده
We report a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a potentially powerful surveillance tool for objective early cancer detection. We describe the design, construction, calibration, and first clinical application of this new system. We demonstrate its accuracy using physical tissue models. We validate its diagnostic ability on a resected colon adenoma, and demonstrate feasibility of in vivo imaging in the oral cavity.
منابع مشابه
Detection of breast cancer using non-invasive X-ray diffraction technique of hair: A preliminary study
Background: An early diagnosis of breast cancer relates directly to an accurate treatment plan and strategy. Early detection of breast cancer before its development would be a significant reduction of morbidity and mortality rates. The aim of this preliminary study is to investigate the sensitivity of Wide Angle X-ray diffraction (WAXRD) method on women hair samples of healthy and breast cancer...
متن کاملشناسایی سرطان پوست براساس الگوی حرارتی در تصاویر فروسرخ
Background and Aim: Skin cancer is the most common type of cancer constitutes and 75% of all cancers in the world. Malignant melanoma is the most invasive and lethal form of skin cancer. The objective of this study was to evaluate infrared thermography in differentiation of benign and malignant skin lesions. Methods: This study was conducted on 120 patients (60 female, 60 male) with a lesio...
متن کاملEarly detection of high-grade squamous intraepithelial lesions in the cervix with quantitative spectroscopic imaging.
Quantitative spectroscopy has recently been extended from a contact-probe to wide-area spectroscopic imaging to enable mapping of optical properties across a wide area of tissue. We train quantitative spectroscopic imaging (QSI) to identify cervical high-grade squamous intraepithelial lesions (HSILs) in 34 subjects undergoing the loop electrosurgical excision procedure (LEEP subjects). QSI's pe...
متن کاملDynamic lymphoscintigraphy in breast cancer patients: feasibility and added value
Introduction: Lymphoscintigraphy is imaging of the lymphatic system and has been integrated into the sentinel node mapping procedures. Lymphoscintigraphy usually encompasses early or delayed static images. However, immediate dynamic imaging of the lymphatic basins and tumors has also been used as an adjunct lymphoscintigraphy imaging. The aim of this study was ...
متن کاملNuclear Morphology Measurements with Angle-Resolved Low Coherence Interferometry For Application To Cell Biology And Early Cancer Detection
The study of intact, living cells using non-invasive optical spectroscopic methods offers the opportunity to assess cellular structure and organization in a way that is not possible with commonly used cell biology imaging techniques. We have developed a novel spectroscopic technique for diagnosing disease at the cellular level based on using low-coherence interferometry (LCI) to detect the angu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Optics express
دوره 16 20 شماره
صفحات -
تاریخ انتشار 2008